A groundbreaking study from the University of Copenhagen and collaborators reveals that individuals exhibit a broad spectrum of molecular signatures of insulin resistance—even among those considered healthy. By applying advanced proteomic analyses to muscle biopsies of over 120 individuals, the research team identified specific protein changes that correlate with insulin sensitivity, challenging the binary classification of people as simply “healthy” or “diabetic”. Source
The detailed molecular fingerprinting approach enables earlier detection of insulin resistance, and holds promise for developing precision-medicine strategies for Type 2 diabetes mellitus—tailoring prevention and treatment to individual molecular profiles rather than applying one-size-fits-all interventions.
Clinically, this means that individuals could be stratified by their molecular insulin-resistance signature long before glycaemic thresholds or overt diabetes, enabling earlier lifestyle or pharmacologic interventions. Researchers propose that therapies might be matched to specific ‘fingerprint’ types of insulin resistance.
Overall, this study underscores the shift from broad diagnostic labels to nuanced molecular stratification in diabetes, heralding a new era of personalised prevention and management.
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