Sex/gender modifies the association between the MC4R p.Ile269Asn mutation and type 2 diabetes in the Mexican population
Abstract Context: Studies in mice and humans suggest that melanocortin-4 receptor (MC4R) deficiency impacts body weight in a sex/gender-dependent manner. However, similar evidence for type 2 diabetes (T2D) is scarce. Objective and design: We investigated whether sex/gender modifies the association between the loss-of-function MC4R p.Ile269Asn mutation and T2D in 6,929 Mexican adults (3,175 T2D cases and 3,754 …